Arsenic in Rice and Rice Products Risk Assessment
Quantitative Cancer Risk Assessment Model
Weights for the Bladder Cancer Model
Note: the weights use in this tab will be used in all risk evaluations. Use reset buttons to apply the weights used in the reportWeights for the Lung Cancer Model
Note: the weights use in this tab will be used in all risk evaluations. Use reset buttons to apply the weights used in the reportFDA Arsenic in Rice and Rice Products Risk Assessment Cancer Model
Version 1.1 (04/01/2016)
Disclaimer
This risk assessment model is a complement to the FDA - Center for Food Safety and Applied Nutrition report "Arsenic in Rice and Rice Products Risk Assessment" available on the FDA web site. Access to the model is provided to enhance understanding of the methods we used in conducting the risk assessment.
The various tabs display different elements of the risk assessment arsenic-cancer model developed for the FDA Arsenic in Rice and Rice Products Risk Assessment. Users can change some of the parameters to explore potential changes in contamination and exposure levels as well as risk estimates and scenario results. Specific scenarios examined in the risk assessment are detailed in the risk assessment report.
Please refer to the risk-assessment report regarding limitations and conclusions of the risk assessment model and results.
Note: the parameters set in this tab will be used in all risk evaluations. Use the reset button to apply the values used in the report
Additional parameters
In the dose-response tab, select different maximum dose values.
By doing that, you can explore graphically the dose-response model
at lower and higher doses.
Dose-Response Model for Bladder Cancer
Dose-Response Model for Lung Cancer
(See the report for details and limitations)
In the contamination tab, you can explore how the contamination estimates changes as a function of the type of rice.
Select from the dropdown list the type of rice for which you want estimates.
Also illustrated are the empirical cumulative distribution function
of the iAs concentration and the impact on the mean iAs concentration
when removing the most contaminated samples.
Contamination Estimates
iAs Contamination of the Rice / Rice products
Weighted Empirical Cumulative Distribution Function
Impact on the mean iAs concentration, when removing the most contaminated samples
(See the report for details and limitations)
In the exposure tab, you can explore how the exposure
to inorganic arsenic changes as the selections change. Select from the dropdown lists
the type of rice, the population/exposure period,
and the gender and ethnicity of the population of interest.
Select the NHANES survey years from which the data will be drawn.
All estimates are for populations or sub-populations in the United States.
Consumption estimates
Rice / Rice product Intake per Capita
Rice / Rice product Intake per Eating Occasion
Exposure estimates
Exposure to iAs from Rice / Rice products
(See the report for details and limitations)
In the risk estimates tab, you can explore how the risk of cancer changes as the selections change.
Select from the dropdown lists the type of rice,
the population/exposure period, and the gender and ethnicity
of the population of interest. Select the
NHANES survey years from which the data will be drawn.
Risk Estimates
Cancer Cases Per Million for Lifetime Exposure (0-50 years) using Per Capita Consumption Estimates
Cancer Cases Per Million for Lifetime Exposure (0-50 years) using Per Eating Occasion Consumption Estimates
(See the report for details and limitations)
In the scenario tab, you can explore how the impact of a mandatory
or voluntary limit on the number of cancer cases per million changes
as the selections change. Select from the dropdown lists the type of rice,
the population/exposure period, and the gender and ethnicity
of the population of interest.
Select the NHANES survey years from which
the data will be drawn as well as the type of cancer for which
you want risk estimates.
Impact on the Risk of Cancer when removing the most contaminated samples (left) or when using a voluntary of mandatory limit (right)
Note: A linear approximation between observations is usedPer Capita
Per Eating Occasion
(See the report for details and limitations)
In the risk estimates for a given dose tab,
you can explore how the cancer case estimates change as the selections
change. Select food intake levels,
mean inorganic arsenic concentration in the food,
and the corresponding standard error of the mean concentration.
Theses selections define the dose for which estimates of cancer cases
per million for lifetime exposure are provided.
Estimates for a given dose
Median Estimated Cancer Cases Per Million (and 90% Confidence Intervals) for Lifetime Exposure (0-50 years)
Contour plots
Median Estimated Cancer Cases Per Million for Lifetime Exposure (0-50 years)
Lower bound
(If empty: lower than .1 over the range)Upper nound
(See the report for details and limitations)